Titans at Jets
Last year when these two teams met, the Jets stunned the 10-0 Titans 34-13. This year it's the Jets, led by rookie quarterback Mark Sanchez, who are undefeated. The Jets boast the No. 1 defense in the league, and offensively Sanchez has played like a veteran. The Titans have lost two very close games despite dominant performances by running back Chris Johnson. Titans quarterback Kerry Collins hasn't been his usual accurate self and defensive mistakes have cost the Titans dearly. If Johnson can have another monster game, however, the Titans might have a chance.
The Pick: New York
Giants at Buccaneers
The Giants are off to a good start this season after disposing of division rivals, the Washington Redskins and the Dallas Cowboys, in their first two games. The Tampa Bay Buccaneers on the other hand, have struggled defensively, allowing 450 yards per game, the second most in the league. Facing a weak secondary, Giants quarterback Eli Manning and his young receivers might have a breakout game. Look for Antonio Pierce and the Giants defense to make it a rough day for Tampa quarterback Byron Leftwich even if injured defensive end Justin Tuck is unable to play.
The Pick: New York
Panthers at Cowboys
Both of these teams' quarterbacks have struggled as of late with turnovers and poor decisions. Last week the Dallas Cowboys' Tony Romo threw three interceptions in the home opener at the new Cowboys Stadium. Offensively, the Cowboys are the second-best team in the league but their defense has been suspect. The Carolina Panthers have struggled on both sides of the ball. Quarterback Jake Delhomme is close to being benched, but it doesn't seem like the Panthers have any other answers besides that. The Cowboys might slow down a bit on offense without rushing juggernaut Marion Barber but the Panthers don't look like they're going to pull out of their slump anytime soon.
The Pick: Dallas
Saints at Bills
New Orleans Saints quarterback Drew Brees has been in a league of his own throughout the first two games this season. Brees has passed for nine touchdowns and averaged 323 passing yards per game. The Saints' defense isn't that high quality, but it doesn't have to be with Brees at the helm. The Buffalo Bills should be 2-0 at this point if not for a costly fumble against the New England Patriots. The Bills are mediocre on both sides of the ball and haven't recorded a rushing touchdown yet this year. Their defense is even worse, ranked 28th in the league. This one won't even be close.
The Pick: New Orleans