Pigskin Pick'em

Seahawks at Steelers

This should be an excellent match-up with two 3-1 teams looking for a reputable victory. The Seattle offense features the powerful running attack of Shaun Alexander and the deep threat of Deion Branch. Standing in their way is the second best defense in the league. The Steelers, coming off a disappointing loss to Arizona, should be out for blood. Running back Willie Parker has been explosive and while the Seahawks' run defense is solid, they'll have to come up with a big game to stop him. Ben Roethlisberger has been stellar all season, finally returning to form after last year's disappointing campaign.

The Pick: Steelers

Jets at Giants

Last week the New York Giants' defensive exploded in a sack-frenzy against the Philadelphia Eagles, racking up a total of 12 takedowns, including six by defensive end Osi Umenyiora. The Jets shouldn't be as much of a pushover. Look for them to expose the Giants' weak secondary with crossing routes to receivers Jerricho Cotchery and Laveranues Coles and then run up the middle with quick hits to avoid the powerful defensive combo of Umenyiora and Michael Strahan. On the Giants side, the defense must have another big game to shore up the inconsistent offense. Quarterback Eli Manning, while showing signs of leadership this season, is still shaky at times. He has looked to receiver Plaxico Burress early and often the past several weeks, and this Sunday should prove no different. If the defense can produce as it did last week, Jets' quarterback Chad Pennington will spend most of the day running for his life. If not, the Giants may be in trouble.

The Pick: Giants

Cowboys at Bills

On Monday night, the NFC East leading Dallas Cowboys travel to Buffalo to take on the 1-3 Bills. This game shouldn't even be close, as the Bills have struggled all season on both sides of the ball, although rookie signal-caller Trent Edwards showed promise last week and may have ignited a quarterback controversy with the injured J.P. Losman, who has failed to throw a touchdown pass so far this season. Cowboys' quarterback Tony Romo, who leads the league with 11 touchdown passes, has led the Cowboys to their first 4-0 start since 1995. Romo leads the league's second best offense against the league's worst defense and that just about says it all. Also adding to the team's defensive woes, three Buffalo starters suffered possible serious injuries last week. Either way, look for Dallas to cruise to 5-0 this week.

The Pick: Cowboys

Bears at Packers

The Sunday night affair features another installment of the epic NFC North rivalry between the Chicago Bears and the Green Bay Packers. The 1-3 Bears travel to Lambeau Field to see if they can slow down the 4-0 Packers. Look for the Packers, however, to ride the wave of emotion generated by last week's historic moment as quarterback Brett Favre broke Dan Marino's career touchdown record, and then added another score to give him 422 in his storied career. The Bears, with the 30th best offense in the NFL, benched starting quarterback Rex Grossman in favor of veteran Brian Griese in last week's loss. Don't expect that to help them this week, with the only possible bright spot coming from punt-return extraordinaire Devin Hester.

The Pick: Packers